Dick moves in your line of work.

[Ideologue]

Seems straightforward enough.

I'l love to give you a mass of drug data and the Guidelines, and see what you came up with.

A solution to all your healthcare woes.  OK, probably not, but after a brief skim of the Guidelines, it doesn't seem like rocket science.  (This does not necessarily mean I'm correct about any of the following, because odds are I am not because I am not steeped in this.)

How, for example, is someone supposed to compare the price of a pediatric drug that has an initial dose of certain amount of mg/kg body weight, is titrated upwards to the final dose, with a possible maximum of 60 mg, with another where the usual dose is 30 mg but at the physician's election may be dosed as low as 20 or as high as 50?

Price per course of treatment (acute condition) or price per day (chronic condition) per C.8.15, no?  For the stepped dose, if this is a chronic condition, I would guess that you average out the cost per day, or, if this is a drug regimen that will last till the end of the patient's days/till adulthood/till puberty/till whatever time, maybe disregard the initial low doses entirely as de minimis and unrepresentative.  As for the varied dose:

C.8.14 The comparable dosage regimen recommended for comparison purposes will normally not be higher than the maximum of the usual recommended dosage in the Product Monograph (or similar information) taking into account relevant clinical variables. The most appropriate strength of the drug product will be chosen for a particular dosage regimen.

Under this guideline, I think that means that 30mg would be used for comparison purposes, as that would be the "usual recommended dosage" as well as "the most appropriate strength," unless it is unreasonable to use it as such.

And how about where the comparative dosage strengths are not the same, and the price of the comparator does not scale linearly as a function of price per mg?

Irrelevant under a price per day/CoT analysis, right?  It's either more expensive on that basis, or it isn't, at the dose (or range of doses) chosen to compare.

[Ideologue]

P.S. WTF is a "vaginal cone"?

[Syt]

Another dick move as played today: people scheduling vitally important conference calls for late Friday afternoon ("because during the week I'm too busy") when you originally planned to start the weekend at 2 pm. 

[Razgovory]

P.S. WTF is a "vaginal cone"?

It's like one of those cones you put around a dog's neck so it doesn't bite at stitches or a cast.  You put one on a woman's vagina so her pussy doesn't turn around and eat her.

[Razgovory]

Or so I've heard...