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CURE for Leukemia Discovered

Started by jimmy olsen, August 10, 2011, 07:08:09 PM

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jimmy olsen

:w00t:

http://www.msnbc.msn.com/id/44090512/ns/health-cancer/

QuoteNew leukemia treatment exceeds 'wildest expectations'

A single shot could be one of the biggest advances in cancer research in decades, scientists say. But the research almost didn't happen

By Robert Bazell Chief science and health correspondent
NBC News
updated 38 minutes ago 2011-08-10T23:20:14


Doctors have treated only three leukemia patients, but the sensational results from a single shot could be one of the most significant advances in cancer research in decades. And it almost never happened.

In the research published Wednesday, doctors at the University of Pennsylvania say the treatment made the most common type of leukemia completely disappear in two of the patients and reduced it by 70 percent in the third. In each of the patients as much as five pounds of cancerous tissue completely melted away in a few weeks, and a year later it is still gone.

The results of the preliminary test "exceeded our wildest expectations," says immunologist Dr. Carl June a member of the Abramson Cancer Center's research team.

Dr. Edgar Engleman, a cancer immunologist at Stanford University School of Medicine who was not involved in the research calls the  results "remarkable ... great stuff."

The Penn scientists targeted chroniclymphocytic leukemia (CLL), the most common type of the blood disease. It strikes some 15,000 people in the United States, mostly adults, and kills 4,300 every year. Chemotherapy and radiation can hold this form of leukemia at bay for years, but until now the only cure has been a bone marrow transplant. A bone marrow transplant requires a suitable match, works only about half the time, and often brings on severe, life-threatening side effects such as pain and infection.

In the Penn experiment, the researchers removed certain types of white blood cells that the body uses to fight disease from the patients. Using a modified, harmless version of HIV, the virus that causes AIDS, they inserted a series of genes into the white blood cells.  These were designed to make to cells target and kill the cancer cells.  After growing a large batch of the genetically engineered white blood cells, the doctors injected them back into the patients.

In similar past experimental treatments for several types of cancer the re-injected white cells killed a few cancer cells and then died out. But the Penn researchers inserted a gene that made the white blood cells multiply by a thousand fold inside the body. The result, as researcher June put it, is that the white blood cells became "serial killers" relentlessly tracking down and killing the cancer cells in the blood, bone marrow and lymph tissue.


As the white cells killed the cancer cells, the patients experienced the fevers and aches and pains that one would expect when the body is fighting off an infection, but beyond that the side effects have been minimal.

Doctors had told Bill Ludwig, one of the research volunteers, that he would die from his leukemia within weeks. Then he got the experimental treatment a year ago.

With tears welling up, he told NBC, "I'm more closer to the people I love and I appreciate them more... I'm getting emotional... the grass is greener and flowers smell wonderful."

The other two patients have chosen to remain anonymous but one who happens to be a scientist himself wrote,  "I am still trying to grasp the enormity of what I am a part of  -- and of what the results will mean to countless others with CLL or other forms of cancer. When I was a young scientist, like many I'm sure, I dreamed that I might make a discovery that would make a difference to mankind – I never imagined I would be part of the experiment."

So why has this remarkable treatment been tried so far on only three patients?

Both the National Cancer Institute and several pharmaceutical companies declined to pay for the research. Neither applicants nor funders discuss the reasons an application is turned down. But good guesses are the general shortage of funds and the concept tried in this experiment was too novel and, thus, too risky for consideration.

The researchers did manage to get a grant from the Alliance for Cancer Gene Therapy, a charity founded by Barbara and Edward Netter after their daughter-in-law died of cancer. The money was enough to finance the trials on the first three patients.

With results for the three  patients published Wednesday simultaneously in the New England Journal of Medicine and Science Translational Medicine, money for further studies -- not just in this one type of leukemia, but in other cancers -- will likely pour in from both the government and drug companies.

Read the New England Journal of Medicine report
NEJM: Redirecting T Cells

It is important to emphasize that there still have been only three patients. Over the past century, many attempts to harness the body's immune system to fight cancer have shown initial success and subsequent failure. So much research remains to be done to prove just how good this treatment is. But it should begin soon, with great vigor.
It is far better for the truth to tear my flesh to pieces, then for my soul to wander through darkness in eternal damnation.

Jet: So what kind of woman is she? What's Julia like?
Faye: Ordinary. The kind of beautiful, dangerous ordinary that you just can't leave alone.
Jet: I see.
Faye: Like an angel from the underworld. Or a devil from Paradise.
--------------------------------------------
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Razgovory

This would have been nice back in 1994 when they thought I had Leukemia. <_<
I've given it serious thought. I must scorn the ways of my family, and seek a Japanese woman to yield me my progeny. He shall live in the lands of the east, and be well tutored in his sacred trust to weave the best traditions of Japan and the Sacred South together, until such time as he (or, indeed his house, which will periodically require infusion of both Southern and Japanese bloodlines of note) can deliver to the South it's independence, either in this world or in space.  -Lettow April of 2011

Raz is right. -MadImmortalMan March of 2017

Ideologue

Kinemalogue
Current reviews: The 'Burbs (9/10); Gremlins 2: The New Batch (9/10); John Wick: Chapter 2 (9/10); A Cure For Wellness (4/10)

Razgovory

Are we going to have Tim post a backlog of news stories now?
I've given it serious thought. I must scorn the ways of my family, and seek a Japanese woman to yield me my progeny. He shall live in the lands of the east, and be well tutored in his sacred trust to weave the best traditions of Japan and the Sacred South together, until such time as he (or, indeed his house, which will periodically require infusion of both Southern and Japanese bloodlines of note) can deliver to the South it's independence, either in this world or in space.  -Lettow April of 2011

Raz is right. -MadImmortalMan March of 2017

garbon

I guess Tim didn't read the last sentence.
"I've never been quite sure what the point of a eunuch is, if truth be told. It seems to me they're only men with the useful bits cut off."
I drank because I wanted to drown my sorrows, but now the damned things have learned to swim.

Razgovory

Quote from: garbon on August 10, 2011, 07:17:26 PM
I guess Tim didn't read the last sentence.

But it should begin soon, with great vigor?
I've given it serious thought. I must scorn the ways of my family, and seek a Japanese woman to yield me my progeny. He shall live in the lands of the east, and be well tutored in his sacred trust to weave the best traditions of Japan and the Sacred South together, until such time as he (or, indeed his house, which will periodically require infusion of both Southern and Japanese bloodlines of note) can deliver to the South it's independence, either in this world or in space.  -Lettow April of 2011

Raz is right. -MadImmortalMan March of 2017

garbon

Quote from: Razgovory on August 10, 2011, 07:25:20 PM
Quote from: garbon on August 10, 2011, 07:17:26 PM
I guess Tim didn't read the last sentence.

But it should begin soon, with great vigor?
Even just that is enough to question whether this thread has an appropriate title. But you are right, that's not what I meant. :P
"I've never been quite sure what the point of a eunuch is, if truth be told. It seems to me they're only men with the useful bits cut off."
I drank because I wanted to drown my sorrows, but now the damned things have learned to swim.

The Brain

It only works on white blood? Racist.
Women want me. Men want to be with me.

Martinus

I thought this thread was about the band.  <_<

Ed Anger

Quote from: Martinus on August 11, 2011, 05:39:48 AM
I thought this thread was about the band.  <_<

That thread is on Fascination Street.
Stay Alive...Let the Man Drive

Palisadoes


garbon

"I've never been quite sure what the point of a eunuch is, if truth be told. It seems to me they're only men with the useful bits cut off."
I drank because I wanted to drown my sorrows, but now the damned things have learned to swim.

Warspite

" SIR – I must commend you on some of your recent obituaries. I was delighted to read of the deaths of Foday Sankoh (August 9th), and Uday and Qusay Hussein (July 26th). Do you take requests? "

OVO JE SRBIJA
BUDALO, OVO JE POSTA